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    depd-5 DEP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    depd-5
    Official Full Name
    DEP domain-containing protein
    Primary source
    WormBase:WBGene00011604
    Locus tag
    CELE_T08A11.1
    See related
    AllianceGenome:WB:WBGene00011604
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of autophagy. Predicted to be part of GATOR1 complex. Predicted to be active in lysosomal membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and familial focal epilepsy with variable foci 1. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See depd-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    17
    Sequence:
    Chromosome: III; NC_003281.10 (4248152..4263148, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene HIT-type domain-containing protein Neighboring gene WD repeat-containing protein 55 Neighboring gene Splicing factor 3B subunit 1 domain-containing protein Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GATOR1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DEP domain-containing protein
    NP_001366728.1
    • Confirmed by transcript evidence
    NP_001420380.1
    • Confirmed by transcript evidence
    NP_001420381.1
    • Confirmed by transcript evidence
    NP_001420382.1
    • Confirmed by transcript evidence
    NP_001420383.1
    • Confirmed by transcript evidence
    NP_001420384.1
    • Confirmed by transcript evidence
    NP_001420385.1
    • Confirmed by transcript evidence
    NP_001420386.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4248152..4263148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381826.1 → NP_001366728.1  DEP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBK0
      Conserved Domains (2) summary
      smart00049
      Location:1332 → 1418
      DEP; Domain found in Dishevelled, Egl-10, and Pleckstrin
      pfam12257
      Location:214 → 493
      IML1; Vacuolar membrane-associated protein Iml1

    2. NM_001433456.1 → NP_001420385.1  DEP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    3. NM_001433457.1 → NP_001420380.1  DEP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    4. NM_001433459.1 → NP_001420382.1  DEP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    5. NM_001433454.1 → NP_001420383.1  DEP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    6. NM_001433455.1 → NP_001420381.1  DEP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    7. NM_001433458.1 → NP_001420384.1  DEP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    8. NM_001433460.1 → NP_001420386.1  DEP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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