let-504 NF-kappa-B-activating protein C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-504
Official Full Name: NF-kappa-B-activating protein C-terminal domain-containing protein
Primary source: WormBase:WBGene00002696
Locus tag: CELE_E01A2.4
See related: AllianceGenome:WB:WBGene00002696
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to several human genes including NKAP (NFKB activating protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-504 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (4129565..4132224, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

E01A2.f (e-PCR)
- UniSTS:324228

E01A2.d (e-PCR)
- UniSTS:324586

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NF-kappa-B-activating protein C-terminal domain-containing protein

NP_491301.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4129565..4132224 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058900.7 → NP_491301.1 NF-kappa-B-activating protein C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491301.1

Status: REVIEWED

UniProtKB/TrEMBL

Q966L6

Conserved Domains (1) summary

pfam06047
Location:398 → 499

SynMuv_product; Ras-induced vulval development antagonist