skr-7 Skp1-related protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: skr-7
Official Full Name: Skp1-related protein
Primary source: WormBase:WBGene00004813
Locus tag: CELE_Y47D7A.1
See related: AllianceGenome:WB:WBGene00004813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cullin family protein binding activity. Involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See skr-7 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_003283.11 (4422427..4423011)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y47D7A_138.a (e-PCR)
- UniSTS:324352

Y47D7A_138.d (e-PCR)
- UniSTS:323685

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Skp1-related protein

NP_504221.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4422427..4423011

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071820.7 → NP_504221.1 Skp1-related protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504221.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDY3

Conserved Domains (2) summary

smart00512
Location:20 → 129

Skp1; Found in Skp1 protein family

pfam01466
Location:103 → 160

Skp1; Skp1 family, dimerization domain