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    ppk-2 PIPK domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk-2
    Official Full Name
    PIPK domain-containing protein
    Primary source
    WormBase:WBGene00004088
    Locus tag
    CELE_Y48G9A.8
    See related
    AllianceGenome:WB:WBGene00004088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to be active in plasma membrane. Is expressed in several structures, including enteric muscle; excretory cell; nervous system; rectum; and reproductive system. Orthologous to several human genes including PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ppk-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (2102295..2107497)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene Protein-tyrosine phosphatase Neighboring gene CsbD family protein;Late embryogenesis abundant protein D-29-like Neighboring gene C2H2-type domain-containing protein Neighboring gene Conserved secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Weinkove D, et al. Dev Biol, 2008 Jan 1. PMID 18037397, Free PMC Article
    2. Role of phosphatidylinositol-4-phosphate 5' kinase (ppk-1) in ovulation of Caenorhabditis elegans. Xu X, et al. Exp Cell Res, 2007 Jul 1. PMID 17475243, Free PMC Article
    3. Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization. Clarke JH, et al. Biochem J, 2013 Aug 15. PMID 23758345, Free PMC Article
    4. RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling. Yan Y, et al. J Cell Biol, 2021 May 3. PMID 33844824, Free PMC Article
    5. The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Norman KR, et al. Cell, 2005 Oct 7. PMID 16213217

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    NOT enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PIPK domain-containing protein
    NP_497500.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2102295..2107497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065099.5 → NP_497500.1  PIPK domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL73
      Conserved Domains (1) summary
      cd17305
      Location:30 → 398
      PIPKc_PIP5KII; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in type II phosphatidylinositol 5-phosphate 4-kinase (PIP5KII) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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