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    snt-1 C2 domain-containing protein;Synaptotagmin-1 [ Caenorhabditis elegans ]

    Gene ID: 174120, updated on 9-Dec-2024

    Summary

    Official Symbol
    snt-1
    Official Full Name
    C2 domain-containing protein;Synaptotagmin-1
    Primary source
    WormBase:WBGene00004921
    Locus tag
    CELE_F31E8.2
    See related
    AllianceGenome:WB:WBGene00004921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium ion binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Involved in several processes, including defecation; regulation of nematode pharyngeal pumping; and synaptic vesicle endocytosis. Located in synaptic vesicle. Is expressed in several structures, including excretory gland cell; gonad; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and congenital myasthenic syndrome 7. Orthologous to several human genes including SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See snt-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (6810963..6816433)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Homeobox domain-containing protein Neighboring gene DUF4091 domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNARE binding  
    enables calcium ion binding PubMed 
    enables calcium ion sensor activity  
    enables calcium ion sensor activity PubMed 
    enables calcium-dependent phospholipid binding  
    enables calcium-dependent phospholipid binding PubMed 
    enables metal ion binding  
    Component Evidence Code Pubs
    is_active_in axon  
    located_in cytoplasmic vesicle  
    is_active_in dense core granule  
    is_active_in exocytic vesicle  
    located_in membrane  
    is_active_in plasma membrane  
    located_in synapse PubMed 
    located_in synapse  
    located_in synaptic vesicle PubMed 
    is_active_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    C2 domain-containing protein;Synaptotagmin-1
    NP_001022129.1
    • Confirmed by transcript evidence
    NP_495394.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6810963..6816433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026958.6 → NP_001022129.1  Synaptotagmin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34693
      Conserved Domains (2) summary
      cd08385
      Location:160 → 282
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:293 → 427
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    2. NM_062993.9 → NP_495394.3  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495394.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95QH7
      Conserved Domains (2) summary
      cd08385
      Location:160 → 282
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:293 → 429
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
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