mboa-7 Lysophospholipid acyltransferase 7 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: mboa-7
Official Full Name: Lysophospholipid acyltransferase 7
Primary source: WormBase:WBGene00008806
Locus tag: CELE_F14F3.3
See related: AllianceGenome:WB:WBGene00008806
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables O-acyltransferase activity. Involved in egg-laying behavior; nematode larval development; and phosphatidylinositol biosynthetic process. Located in intracellular membrane-bounded organelle. Is expressed in body wall musculature; hermaphrodite gonad; intestine; pharyngeal muscle cell; and vulva. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Knockdown of class III PI 3-kinase causes growth defects in mboa-7 mutants.
Title: Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans.
mboa-7 encodes a member of the membrane-bound O-acyltransferase family, suggesting that mboa-7 is lysoPI acyltransferase.
Title: Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.

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Function	Evidence Code	Pubs
enables O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	IBA Inferred from Biological aspect of Ancestor more info

NP_509760.2

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