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    rsbp-1 Abi_C domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rsbp-1
    Official Full Name
    Abi_C domain-containing protein
    Primary source
    WormBase:WBGene00011531
    Locus tag
    CELE_T06D10.1
    See related
    AllianceGenome:WB:WBGene00011531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cell body and neuron projection. Is expressed in body wall musculature; muscle cell; nervous system; pharynx; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rsbp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (9070850..9075077, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PX domain-containing protein Neighboring gene DNA repair and recombination protein RAD54-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Chromatin assembly factor 1 subunit A dimerization domain-containing protein Neighboring gene Fatty acid desaturase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RSBP-1 is a membrane-targeting subunit required by the Galpha(q)-specific but not the Galpha(o)-specific R7 regulator of G protein signaling in Caenorhabditis elegans. Porter MY, et al. Mol Biol Cell, 2010 Jan 15. PMID 19923320, Free PMC Article
    2. Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking. Maza N, et al. Nat Neurosci, 2022 Sep. PMID 35982154, Free PMC Article
    3. D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons. Wani KA, et al. PLoS One, 2012. PMID 22629462, Free PMC Article
    4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EAT-16 and RSBP-1 act together to selectively inhibit D1 dopamine receptor signaling in cholinergic motor neurons to modulate locomotion behavior.
      Title: D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Abi_C domain-containing protein
    NP_492439.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9070850..9075077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060038.9 → NP_492439.1  Abi_C domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U379
    Nucleotide Protein
    Heading Accession and Version

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