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    asd-2 K Homology domain-containing protein;RNA-binding protein asd-2 [ Caenorhabditis elegans ]

    Gene ID: 188703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asd-2
    Official Full Name
    K Homology domain-containing protein;RNA-binding protein asd-2
    Primary source
    WormBase:WBGene00006423
    Locus tag
    CELE_T21G5.5
    See related
    AllianceGenome:WB:WBGene00006423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in P granule and nucleus. Part of ribonucleoprotein complex. Is expressed in body wall musculature; hypodermis; and pharyngeal muscle cell. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asd-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (6877059..6892143, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing protein Neighboring gene Tyrosine-protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine receptor class beta-15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Ohno G, et al. Genes Dev, 2008 Feb 1. PMID 18230701, Free PMC Article
    2. C. elegans star proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development. Lee MH, et al. Adv Exp Med Biol, 2010. PMID 21189689
    3. KH domain containing RNA-binding proteins coordinate with microRNAs to regulate Caenorhabditis elegans development. Haskell D, et al. G3 (Bethesda), 2021 Feb 9. PMID 33585875, Free PMC Article
    4. Switch-like regulation of tissue-specific alternative pre-mRNA processing patterns revealed by customized fluorescence reporters. Kuroyanagi H. Worm, 2013 Jul 1. PMID 24778931, Free PMC Article
    5. High-affinity consensus binding of target RNAs by the STAR/GSG proteins GLD-1, STAR-2 and Quaking. Carmel AB, et al. BMC Mol Biol, 2010 Jun 23. PMID 20573244, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
      Title: Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
    2. We isolated several switching-defective mutants and identified the alternative splicing defective-2 (asd-2) gene, encoding a novel member of the evolutionarily conserved STAR (signal transduction activators of RNA) family of RNA-binding proteins.
      Title: STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA intronic binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    K Homology domain-containing protein;RNA-binding protein asd-2
    NP_001021625.1
    • Partially confirmed by transcript evidence
    NP_001021626.1
    • Confirmed by transcript evidence
    NP_001021627.1
    • Confirmed by transcript evidence
    NP_001250340.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6877059..6892143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001263411.2 → NP_001250340.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4YW53, G4S8D2
      Conserved Domains (2) summary
      cd02395
      Location:161 → 283
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16544
      Location:95 → 145
      STAR_dimer; Homodimerization region of STAR domain protein

    2. NM_001026455.6 → NP_001021626.1  RNA-binding protein asd-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFF1
      Conserved Domains (2) summary
      cd02395
      Location:89 → 211
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16544
      Location:23 → 74
      STAR_dimer; Homodimerization region of STAR domain protein

    3. NM_001026456.4 → NP_001021627.1  RNA-binding protein asd-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFF1, G5EFG9, O02065
      Conserved Domains (2) summary
      cd02395
      Location:131 → 253
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16544
      Location:65 → 116
      STAR_dimer; Homodimerisation region of STAR domain protein

    4. NM_001026454.5 → NP_001021625.1  RNA-binding protein asd-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFF1
      Conserved Domains (2) summary
      cd02395
      Location:89 → 211
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16544
      Location:23 → 74
      STAR_dimer; Homodimerization region of STAR domain protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFF1.1

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