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    lagr-1 putative ceramide synthase lagr-1 [ Caenorhabditis elegans ]

    Gene ID: 189370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lagr-1
    Official Full Name
    putative ceramide synthase lagr-1
    Primary source
    WormBase:WBGene00006505
    Locus tag
    CELE_Y6B3B.10
    See related
    AllianceGenome:WB:WBGene00006505
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Is expressed in pharynx. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 8. Orthologous to human CERS1 (ceramide synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lagr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (13724577..13732046, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein;TRAM domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene inositol-phosphate phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition. Zhu H, et al. J Biol Chem, 2024 Jun. PMID 38677510, Free PMC Article
    2. Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans. Mosbech MB, et al. PLoS One, 2013. PMID 23894595, Free PMC Article
    3. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. van Ham TJ, et al. PLoS Genet, 2008 Mar 21. PMID 18369446, Free PMC Article
    4. Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans. Pandey T, et al. Exp Gerontol, 2019 Jun. PMID 30825547
    5. Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1. Sharma S, et al. Mol Neurobiol, 2021 Jan. PMID 32894501

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ceramide synthase lagr-1
    NP_493403.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13724577..13732046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061002.4 → NP_493403.1  putative ceramide synthase lagr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493403.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XWE9
      Conserved Domains (1) summary
      smart00724
      Location:102 → 320
      TLC; TRAM, LAG1 and CLN8 homology domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XWE9.1

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