U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    aco-2 putative aconitate hydratase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 176121, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    aco-2
    Official Full Name
    putative aconitate hydratase, mitochondrial
    Primary source
    WormBase:WBGene00000041
    Locus tag
    CELE_F54H12.1
    See related
    AllianceGenome:WB:WBGene00000041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Predicted to be involved in tricarboxylic acid cycle. Located in mitochondrion. Is expressed widely. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See aco-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (7973717..7977355)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like protein 6-interacting protein 4 Neighboring gene Uncharacterized protein Neighboring gene putative elongation factor 1-beta/1-delta 1 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene tRNA-Phe Neighboring gene ncRNA Neighboring gene Calpain clp-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An aco-2::gfp knock-in enables the monitoring of mitochondrial morphology throughout C. elegans lifespan. Begelman DV, et al. MicroPubl Biol, 2022. PMID 35903774, Free PMC Article
    2. Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans. Gourley BL, et al. J Biol Chem, 2003 Jan 31. PMID 12438312
    3. Oligonucleotide Array Comparative Genomic Hybridization (oaCGH) based characterization of genetic deficiencies as an aid to gene mapping in Caenorhabditis elegans. Jones MR, et al. BMC Genomics, 2007 Nov 7. PMID 17986355, Free PMC Article
    4. NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans. Yang R, et al. Cell Rep, 2022 Jan 11. PMID 35021096
    5. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Yoneda T, et al. J Cell Sci, 2004 Aug 15. PMID 15280428

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative aconitate hydratase, mitochondrial
    NP_498738.2
    • Confirmed by transcript evidence
    NP_741235.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7973717..7977355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171200.5 → NP_741235.1  putative aconitate hydratase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741235.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34455, Q8IG17, Q8WQF0
      Conserved Domains (3) summary
      cd01584
      Location:92 → 502
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:581 → 729
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:42 → 769
      aconitase_mito; aconitate hydratase, mitochondrial

    2. NM_066337.8 → NP_498738.2  putative aconitate hydratase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498738.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34455
      Conserved Domains (3) summary
      cd01584
      Location:1 → 408
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:487 → 635
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:1 → 675
      aconitase_mito; aconitate hydratase, mitochondrial
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34455.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous