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    metl-13 Methyltransferase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    metl-13
    Official Full Name
    Methyltransferase domain-containing protein
    Primary source
    WormBase:WBGene00015282
    Locus tag
    CELE_C01B10.8
    See related
    AllianceGenome:WB:WBGene00015282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Is expressed in intestine. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See metl-13 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (6635089..6638155)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene ncRNA Neighboring gene Bis(5'-adenosyl)-triphosphatase Neighboring gene Secreted protein;TransThyretin-Related family domain Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the biochemical activity and tumor-promoting role of the dual protein methyltransferase METL-13/METTL13 in Caenorhabditis elegans. Engelfriet ML, et al. PLoS One, 2023. PMID 37347777, Free PMC Article
    2. N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Liberman N, et al. Sci Adv, 2020 Apr. PMID 32494643, Free PMC Article
    3. Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness. Geens E, et al. Life Sci Alliance, 2023 Jun. PMID 37059473, Free PMC Article
    4. Proteomic analysis of Caenorhabditis elegans. Jeong PY, et al. Methods Mol Biol, 2009. PMID 19381582
    5. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari M, et al. Mol Cell, 2004 Feb 27. PMID 14992718

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Methyltransferase domain-containing protein
    NP_501024.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6635089..6638155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068623.6 → NP_501024.1  Methyltransferase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17539
      Conserved Domains (2) summary
      pfam01564
      Location:337 → 572
      Spermine_synth; Spermine/spermidine synthase domain
      cl17173
      Location:44 → 158
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version

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