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    nra-4 Nicotinic receptor-associated protein 4 [ Caenorhabditis elegans ]

    Gene ID: 3565008, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nra-4
    Official Full Name
    Nicotinic receptor-associated protein 4
    Primary source
    WormBase:WBGene00015344
    Locus tag
    CELE_C02E11.1
    See related
    AllianceGenome:WB:WBGene00015344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in protein-containing complex assembly. Located in endoplasmic reticulum. Is expressed in several structures, including excretory cell; intestine; nervous system; non-striated muscle; and reproductive system. Orthologous to human NOMO1 (NODAL modulator 1); NOMO2 (NODAL modulator 2); and NOMO3 (NODAL modulator 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nra-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (1042691..1048582, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene G protein-coupled receptor;Seven TM Receptor Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nematode model to evaluate microdeletion phenotype expression. Antkowiak KR, et al. G3 (Bethesda), 2024 Feb 7. PMID 37956108, Free PMC Article
    2. An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse. Almedom RB, et al. EMBO J, 2009 Sep 2. PMID 19609303, Free PMC Article
    3. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Golden TR, et al. Aging Cell, 2008 Dec. PMID 18778409, Free PMC Article
    4. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449
    5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nicotinic receptor-associated protein 4
    NP_503367.1
    • Confirmed by transcript evidence
    NP_872191.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1042691..1048582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182391.2 → NP_872191.1  Nicotinic receptor-associated protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KYE0, Q9UAN9

    2. NM_070966.4 → NP_503367.1  Nicotinic receptor-associated protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9UAN9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2KYE0.1

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