iscu-1 NIF system FeS cluster assembly NifU N-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: iscu-1
Official Full Name: NIF system FeS cluster assembly NifU N-terminal domain-containing protein
Primary source: WormBase:WBGene00012885
Locus tag: CELE_Y45F10D.4
See related: AllianceGenome:WB:WBGene00012885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and ferrous iron binding activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be active in mitochondrial matrix. Is expressed in body wall musculature; hypodermis; and intestine. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See iscu-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (13783962..13784680)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y45F10D.4 (e-PCR)
- UniSTS:316207

Y45F10D.11 (e-PCR)
- UniSTS:308180

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NIF system FeS cluster assembly NifU N-terminal domain-containing protein

NP_502658.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13783962..13784680

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070257.4 → NP_502658.1 NIF system FeS cluster assembly NifU N-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502658.1

Status: REVIEWED

UniProtKB/TrEMBL

O45948

Conserved Domains (1) summary

PRK11325
Location:27 → 151

PRK11325; scaffold protein; Provisional