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    cmtr-2 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 [ Caenorhabditis elegans ]

    Gene ID: 182563, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cmtr-2
    Official Full Name
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
    Primary source
    WormBase:WBGene00021502
    Locus tag
    CELE_Y40D12A.1
    See related
    AllianceGenome:WB:WBGene00021502
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be active in cytoplasm and nucleus. Orthologous to human CMTR2 (cap methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cmtr-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (6615414..6620051)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein-tyrosine phosphatase Neighboring gene Serpentine Receptor, class T Neighboring gene Carboxypeptidase Neighboring gene Uncharacterized protein Neighboring gene putative coatomer subunit delta Neighboring gene Calcitonin receptor-like protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
    NP_498461.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6615414..6620051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066060.8 → NP_498461.3  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498461.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76726
      Conserved Domains (1) summary
      pfam01728
      Location:97 → 306
      FtsJ; FtsJ-like methyltransferase
    Nucleotide Protein
    Heading Accession and Version

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