spin-4 MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spin-4
Official Full Name: MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein
Primary source: WormBase:WBGene00013739
Locus tag: CELE_Y111B2A.19
See related: AllianceGenome:WB:WBGene00013739
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS1 (SPNS lysolipid transporter 1, lysophospholipid); SPNS2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate); and SPNS3 (SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spin-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (12688318..12698249)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPIN-4/Spinster supports sperm activation in C. elegans via sphingosine-1-phosphate transport.
Title: SPIN-4/Spinster supports sperm activation in C. elegans via sphingosine-1-phosphate transport.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y111B2D.h (e-PCR)
- UniSTS:323462

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein

NP_001368702.1

Confirmed by transcript evidence

NP_001380236.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12688318..12698249

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392221.1 → NP_001380236.1 Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DV80

Conserved Domains (1) summary

cd17328
Location:28 → 446

MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters
NM_001379966.1 → NP_001368702.1 MFS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DQ22

Conserved Domains (1) summary

cd17328
Location:1 → 294

MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters