ccpp-6 Cytosolic carboxypeptidase 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ccpp-6
Official Full Name: Cytosolic carboxypeptidase 6
Primary source: WormBase:WBGene00017136
Locus tag: CELE_EEED8.6
See related: AllianceGenome:WB:WBGene00017136
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables metallocarboxypeptidase activity. Involved in egg-laying behavior; protein deglutamylation; and proteolysis. Predicted to be active in ciliary basal body and cytoplasm. Is expressed in nervous system. Orthologous to human AGBL4 (AGBL carboxypeptidase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ccpp-6 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (5384137..5387317, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

two evolutionarily divergent systems identify C. elegans CCPP-6 and its mammalian ortholog CCP5 as a tubulin deglutamylase
Title: Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EEED8.7 (e-PCR)
- UniSTS:316514

EEED8.6 (e-PCR)
- UniSTS:313994

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	TAS Traceable Author Statement more info	PubMed
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deglutamylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cytosolic carboxypeptidase 6

NP_495012.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5384137..5387317 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062611.6 → NP_495012.2 Cytosolic carboxypeptidase 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495012.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09296

Conserved Domains (1) summary

cd06908
Location:153 → 418

M14_AGBL4_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-4 and related proteins