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    C28H8.3 putative helicase C28H8.3 [ Caenorhabditis elegans ]

    Gene ID: 175834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C28H8.3
    Official Full Name
    putative helicase C28H8.3
    Primary source
    WormBase:WBGene00016194
    Locus tag
    CELE_C28H8.3
    See related
    AllianceGenome:WB:WBGene00016194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; helicase activity; and nucleic acid binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human DDX60L (DExD/H-box 60 like) and DDX60 (DExD/H-box helicase 60). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C28H8.3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (5908700..5914729)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Zinc finger protein dpff-1 Neighboring gene ER lumen protein-retaining receptor erd-2.2 Neighboring gene ncRNA Neighboring gene Tryptophan 2,3-dioxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
    2. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
    3. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
    4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative helicase C28H8.3
    NP_498283.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5908700..5914729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065882.6 → NP_498283.1  putative helicase C28H8.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498283.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09475
      Conserved Domains (3) summary
      smart00490
      Location:1274 → 1351
      HELICc; helicase superfamily c-terminal domain
      COG4581
      Location:782 → 1529
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      pfam00270
      Location:789 → 945
      DEAD; DEAD/DEAH box helicase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09475.2

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