catp-5 Cation-transporting ATPase;Cation-transporting ATPase catp-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: catp-5
Official Full Name: Cation-transporting ATPase;Cation-transporting ATPase catp-5
Primary source: WormBase:WBGene00019493
Locus tag: CELE_K07E3.7
See related: AllianceGenome:WB:WBGene00019493
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables polyamine transmembrane transporter activity. Involved in polyamine transmembrane transport. Located in apical plasma membrane. Is expressed in amphid neurons; excretory cell; germ cell; gonad; and intestine. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to several human genes including ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See catp-5 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (8089807..8098863, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CATP-5 represents the first P(5)-type ATPase that is associated with the plasma membrane, being expressed in the apical membrane of intestinal cells and the excretory cell.
Title: Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference.

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General gene information

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Markers

K07E3.6 (e-PCR)
- UniSTS:312405

K07E3.7 (e-PCR)
- UniSTS:315269

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables polyamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables polyamine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyamine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cation-transporting ATPase;Cation-transporting ATPase catp-5

NP_001309699.1

Confirmed by transcript evidence

NP_001379600.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8089807..8098863 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392807.1 → NP_001379600.1 Cation-transporting ATPase catp-5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10461, Q21286, Q65ZI7, Q65ZI8

Conserved Domains (2) summary

cd07542
Location:165 → 1022

P-type_ATPase_cation; P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p

pfam12409
Location:24 → 130

P5-ATPase; P5-type ATPase cation transporter
NM_001322625.4 → NP_001309699.1 Cation-transporting ATPase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10461, Q21286, Q65ZI7, Q65ZI8

UniProtKB/TrEMBL

A0A131MBX4

Conserved Domains (6) summary

TIGR01657
Location:52 → 1125

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:247 → 490

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:52 → 154

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:614 → 667

Cation_ATPase; Cation transport ATPase (P-type)

cl02929
Location:966 → 1136

Cation_ATPase_C; Cation transporting ATPase, C-terminus

cl21460
Location:846 → 910

HAD_like; Haloacid Dehalogenase-like Hydrolases