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    gyf-1 GYF domain-containing protein gyf-1 [ Caenorhabditis elegans ]

    Gene ID: 174103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gyf-1
    Official Full Name
    GYF domain-containing protein gyf-1
    Primary source
    WormBase:WBGene00016002
    Locus tag
    CELE_C18H9.3
    See related
    AllianceGenome:WB:WBGene00016002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gyf-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (6684235..6692729)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene VWFA domain-containing protein Neighboring gene pseudo Neighboring gene Intraflagellar transport protein 74 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development. Mayya VK, et al. Nucleic Acids Res, 2021 May 21. PMID 33758928, Free PMC Article
    2. Autofluorescence as a noninvasive biomarker of senescence and advanced glycation end products in Caenorhabditis elegans. Komura T, et al. NPJ Aging Mech Dis, 2021 Jun 7. PMID 34099724, Free PMC Article
    3. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity. Snoznik C, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34593637, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.
      Title: microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GYF domain-containing protein gyf-1
    NP_001343744.1
    • Confirmed by transcript evidence
    NP_001343745.1
    • Confirmed by transcript evidence
    NP_001343746.1
    • Confirmed by transcript evidence
    NP_001343747.1
    • Confirmed by transcript evidence
    NP_495360.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6684235..6692729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356866.2 → NP_001343745.1  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      PTZ00121
      Location:565 → 961
      PTZ00121; MAEBL; Provisional
      smart00444
      Location:457 → 513
      GYF; Contains conserved Gly-Tyr-Phe residues

    2. NM_062959.3 → NP_495360.2  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495360.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09237
      Conserved Domains (3) summary
      smart00444
      Location:389 → 445
      GYF; Contains conserved Gly-Tyr-Phe residues
      pfam07926
      Location:507 → 608
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam13863
      Location:516 → 616
      DUF4200; Domain of unknown function (DUF4200)

    3. NM_001356864.3 → NP_001343746.1  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A2C9C305, A0A2C9C367, A0A2C9C3A1, A0A2C9C3E9, Q09237, Q09482
      Conserved Domains (2) summary
      PTZ00121
      Location:568 → 964
      PTZ00121; MAEBL; Provisional
      smart00444
      Location:460 → 516
      GYF; Contains conserved Gly-Tyr-Phe residues

    4. NM_001356865.3 → NP_001343744.1  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      PTZ00121
      Location:500 → 896
      PTZ00121; MAEBL; Provisional
      smart00444
      Location:392 → 448
      GYF; Contains conserved Gly-Tyr-Phe residues

    5. NM_001356867.3 → NP_001343747.1  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09237.4

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