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    dli-1 Dynein light intermediate chain [ Caenorhabditis elegans ]

    Gene ID: 178260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dli-1
    Official Full Name
    Dynein light intermediate chain
    Primary source
    WormBase:WBGene00001007
    Locus tag
    CELE_C39E9.14
    See related
    AllianceGenome:WB:WBGene00001007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dynein heavy chain binding activity. Involved in regulation of dendrite morphogenesis and retrograde axonal transport. Located in microtubule plus-end and neuron projection. Is expressed in ciliated neurons; hypodermis; and pharynx. Orthologous to several human genes including DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dli-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (13096982..13098792, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Proline-rich protein PRCC Neighboring gene SAP domain-containing protein Neighboring gene Replication factor C subunit 3 Neighboring gene Putative exosome complex component RRP41 Neighboring gene Mitochondrial import inner membrane translocase subunit Tim10B Neighboring gene RAP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic dynein light intermediate chain is required for discrete aspects of mitosis in Caenorhabditis elegans. Yoder JH, et al. Mol Biol Cell, 2001 Oct. PMID 11598181, Free PMC Article
    2. Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells. Zhu T, et al. J Cell Sci, 2017 Dec 1. PMID 29074578, Free PMC Article
    3. Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators. Pecreaux J, et al. Curr Biol, 2006 Nov 7. PMID 17084695
    4. A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. Zhou K, et al. J Cell Biol, 2009 Jul 27. PMID 19635841, Free PMC Article
    5. The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. Arimoto M, et al. J Neurosci, 2011 Feb 9. PMID 21307258, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dynein light intermediate chain
    NP_502518.2
    • Confirmed by transcript evidence
    NP_502519.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13096982..13098792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070118.7 → NP_502519.2  Dynein light intermediate chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502519.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECK7
      Conserved Domains (2) summary
      pfam05783
      Location:26 → 431
      DLIC; Dynein light intermediate chain (DLIC)
      cl21455
      Location:220 → 283
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_070117.10 → NP_502518.2  Dynein light intermediate chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502518.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED34
      Conserved Domains (2) summary
      pfam05783
      Location:26 → 433
      DLIC; Dynein light intermediate chain (DLIC)
      cl21455
      Location:220 → 285
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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