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    dim-1 Disorganized muscle protein 1 [ Caenorhabditis elegans ]

    Gene ID: 181062, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dim-1
    Official Full Name
    Disorganized muscle protein 1
    Primary source
    WormBase:WBGene00001000
    Locus tag
    CELE_C18A11.7
    See related
    AllianceGenome:WB:WBGene00001000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in axon guidance. Predicted to be located in cytoplasm. Is expressed in body wall musculature. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dim-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (8050466..8058220, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene XO lethal protein 1 Neighboring gene SH2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF4309 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved detection of small deletions in complex pools of DNA. Edgley M, et al. Nucleic Acids Res, 2002 Jun 15. PMID 12060690, Free PMC Article
    2. Immunolocalization of Disorganized Muscle Protein-1 in Different Life Stages of Human Lymphatic Filariid, Brugia malayi. Kushwaha V, et al. Acta Parasitol, 2020 Dec. PMID 32500507, Free PMC Article
    3. Disorganized muscle protein-1 (DIM-1) of filarial parasite Brugia malayi: cDNA cloning, expression, purification, structural modeling and its potential as vaccine candidate for human filarial infection. Kushwaha V, et al. Vaccine, 2014 Mar 26. PMID 24513011
    4. DIM-1, a novel immunoglobulin superfamily protein in Caenorhabditis elegans, is necessary for maintaining bodywall muscle integrity. Rogalski TM, et al. Genetics, 2003 Mar. PMID 12663531, Free PMC Article
    5. A Proteomic Analysis Provides Novel Insights into the Stress Responses of Caenorhabditis elegans towards Nematicidal Cry6A Toxin from Bacillus thuringiensis. Wang B, et al. Sci Rep, 2017 Oct 26. PMID 29074967, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The short DIM-1 protein isoform consists entirely of three Ig repeats and is sufficient for wild-type bodywall muscle structure and stability
      Title: DIM-1, a novel immunoglobulin superfamily protein in Caenorhabditis elegans, is necessary for maintaining bodywall muscle integrity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Disorganized muscle protein 1
    NP_001024420.1
    • Confirmed by transcript evidence
    NP_001024421.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8050466..8058220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029249.6 → NP_001024420.1  Disorganized muscle protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18066, Q8MZK1
      Conserved Domains (4) summary
      cd00096
      Location:560 → 624
      Ig; Immunoglobulin domain
      smart00408
      Location:336 → 406
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:323 → 415
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:422 → 517
      Ig; Immunoglobulin domain

    2. NM_001029250.5 → NP_001024421.1  Disorganized muscle protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024421.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18066
      Conserved Domains (4) summary
      cd00096
      Location:244 → 308
      Ig; Immunoglobulin domain
      smart00408
      Location:20 → 90
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:7 → 99
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:106 → 201
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18066.3

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