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    sel-8 Protein lag-3 [ Caenorhabditis elegans ]

    Gene ID: 175464, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sel-8
    Official Full Name
    Protein lag-3
    Primary source
    WormBase:WBGene00004765
    Locus tag
    CELE_C32A3.1
    See related
    AllianceGenome:WB:WBGene00004765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor binding activity; Notch binding activity; and transcription coactivator activity. Involved in several processes, including Notch signaling pathway; positive regulation of stem cell proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sel-8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (3612951..3627142, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein mS31 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of protein-interaction maps to formulate biological questions. Boulton SJ, et al. Curr Opin Chem Biol, 2001 Feb. PMID 11166649
    2. Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Wilson JJ, et al. Cell, 2006 Mar 10. PMID 16530045
    3. SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans. Doyle TG, et al. Proc Natl Acad Sci U S A, 2000 Jul 5. PMID 10884418, Free PMC Article
    4. Two classes of active transcription sites and their roles in developmental regulation. Robinson-Thiewes S, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33033228, Free PMC Article
    5. Mastermind is a putative activator for Notch. Petcherski AG, et al. Curr Biol, 2000 Jun 29. PMID 10898989

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two classes of active transcription sites and their roles in developmental regulation.
      Title: Two classes of active transcription sites and their roles in developmental regulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mesodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lag-3
    NP_001021195.1
    • Confirmed by transcript evidence
    NP_001370114.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3612951..3627142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001384056.2 → NP_001370114.1  Protein lag-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09260, Q9NGS2
      Conserved Domains (1) summary
      pfam11498
      Location:23 → 490
      Activator_LAG-3; Transcriptional activator LAG-3

    2. NM_001026024.4 → NP_001021195.1  Protein lag-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021195.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09260
      Conserved Domains (1) summary
      pfam11498
      Location:1 → 468
      Activator_LAG-3; Transcriptional activator LAG-3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09260.2

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