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    cyp-14A4 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 187573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp-14A4
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00011009
    Locus tag
    CELE_R04D3.1
    See related
    AllianceGenome:WB:WBGene00011009
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; hereditary spastic paraplegia 56; and leukemia (multiple). Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-14A4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (13282043..13284197, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene tRNA-Tyr Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan. Lim SYM, et al. J Appl Toxicol, 2024 Nov. PMID 38472099
    2. High-Content C. elegans Screen Identifies Natural Compounds Impacting Mitochondria-Lipid Homeostasis and Promoting Healthspan. Maglioni S, et al. Cells, 2021 Dec 29. PMID 35011662, Free PMC Article
    3. The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Mao K, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36445965, Free PMC Article
    4. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CYtochrome P450 family
    NP_510207.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13282043..13284197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077806.5 → NP_510207.1  CYtochrome P450 family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED86
      Conserved Domains (1) summary
      pfam00067
      Location:28 → 483
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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