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    cpd-2 Peptidase M14 carboxypeptidase A domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpd-2
    Official Full Name
    Peptidase M14 carboxypeptidase A domain-containing protein
    Primary source
    WormBase:WBGene00012073
    Locus tag
    CELE_T27A8.1
    See related
    AllianceGenome:WB:WBGene00012073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metallocarboxypeptidase activity. Involved in regulation of muscle contraction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in alcohol dependence; carboxypeptidase N deficiency; coronary artery disease; obesity; and type 2 diabetes mellitus. Orthologous to human CPE (carboxypeptidase E); CPM (carboxypeptidase M); and CPN1 (carboxypeptidase N subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpd-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (16049873..16054646)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model. Sarkar A, et al. Biochim Biophys Acta Mol Cell Res, 2022 Dec. PMID 35998789
    2. Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans. Stawicki TM, et al. PLoS Genet, 2013 May. PMID 23658528, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase M14 carboxypeptidase A domain-containing protein
    NP_510625.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16049873..16054646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078224.8 → NP_510625.2  Peptidase M14 carboxypeptidase A domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510625.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22825
      Conserved Domains (2) summary
      cd11308
      Location:358 → 433
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd03858
      Location:58 → 352
      M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    Nucleotide Protein
    Heading Accession and Version

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