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    cpr-2 Peptidase C1A papain C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185355, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpr-2
    Official Full Name
    Peptidase C1A papain C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00000782
    Locus tag
    CELE_F36D3.9
    See related
    AllianceGenome:WB:WBGene00000782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpr-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (16532936..16534100, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF1248 domain-containing protein Neighboring gene DUF1248 domain-containing protein Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorothioate-DNA bacterial diet reduces the ROS levels in C. elegans while improving locomotion and longevity. Huang Q, et al. Commun Biol, 2021 Nov 25. PMID 34824369, Free PMC Article
    2. Changes in Caenorhabditis elegans life span and selective innate immune genes during Staphylococcus aureus infection. JebaMercy G, et al. Folia Microbiol (Praha), 2011 Sep. PMID 21853381
    3. A meta-analysis of RNA-Seq studies to identify novel genes that regulate aging. Bairakdar MD, et al. Exp Gerontol, 2023 Mar. PMID 36731807, Free PMC Article
    4. Per- and polyfluoroalkyl substances enhance Staphylococcus aureus pathogenicity and impair host immune response. Mangu JCK, et al. Environ Pollut, 2022 Dec 1. PMID 36181932
    5. Identification and Functional Analysis of Cytokine-Like Protein CLEC-47 in Caenorhabditis elegans. Pan W, et al. mBio, 2021 Oct 26. PMID 34634942, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase C1A papain C-terminal domain-containing protein
    NP_507186.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16532936..16534100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074785.8 → NP_507186.3  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507186.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45466
      Conserved Domains (1) summary
      cd02620
      Location:84 → 323
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    Nucleotide Protein
    Heading Accession and Version

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