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    trul-1 E3 ubiquitin-protein ligase trul-1 [ Caenorhabditis elegans ]

    Gene ID: 173412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trul-1
    Official Full Name
    E3 ubiquitin-protein ligase trul-1
    Primary source
    WormBase:WBGene00015194
    Locus tag
    CELE_B0432.13
    See related
    AllianceGenome:WB:WBGene00015194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and replication fork processing. Predicted to be located in chromosome. Predicted to be active in nucleus and site of DNA damage. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trul-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (279135..282576, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein;Transposase Neighboring gene CIP2A N-terminal domain-containing protein Neighboring gene Deoxyribonuclease TATDN3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Metallo-beta-lactamase domain-containing protein Neighboring gene Lant_dehydr_C domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication. Sonneville R, et al. Elife, 2019 Sep 23. PMID 31545170, Free PMC Article
    2. Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements. Deng L, et al. Mol Cell, 2019 Mar 7. PMID 30849395, Free PMC Article
    3. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase trul-1
    NP_001370339.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      279135..282576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383776.2 → NP_001370339.1  E3 ubiquitin-protein ligase trul-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90990
      Conserved Domains (2) summary
      TIGR02169
      Location:84 → 261
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd16481
      Location:12 → 54
      RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90990.3

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