sulp-2 STAS domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: sulp-2
Official Full Name: STAS domain-containing protein
Primary source: WormBase:WBGene00017464
Locus tag: CELE_F14D12.5
See related: AllianceGenome:WB:WBGene00017464
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables sulfate transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport and sulfate transmembrane transport. Located in basolateral plasma membrane and non-motile cilium. Is expressed in dopaminergic neurons and intestine. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); calcium oxalate nephrolithiasis; diarrhea (multiple); and goiter. Orthologous to several human genes including SLC26A1 (solute carrier family 26 member 1); SLC26A3 (solute carrier family 26 member 3); and SLC26A4 (solute carrier family 26 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in inorganic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in oxalate transport	IEA Inferred from Electronic Annotation more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_508944.1

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