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    emb-8 NADPH--cytochrome P450 reductase [ Caenorhabditis elegans ]

    Gene ID: 175710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    emb-8
    Official Full Name
    NADPH--cytochrome P450 reductase
    Primary source
    WormBase:WBGene00001262
    Locus tag
    CELE_K10D2.6
    See related
    AllianceGenome:WB:WBGene00001262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable FMN binding activity; NADPH-hemoprotein reductase activity; and flavin adenine dinucleotide binding activity. Involved in eggshell formation and lipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome with disordered steroidogenesis; congenital adrenal hyperplasia; and cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (cytochrome p450 oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See emb-8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (5196680..5199677, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 1 regulatory subunit 7 Neighboring gene Protein HIRA;Protein HIRA-like C-terminal domain-containing protein Neighboring gene Molybdopterin synthase sulfur carrier subunit Neighboring gene ATPase morc-1 Neighboring gene t-SNARE coiled-coil homology domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo. Leung MC, et al. Toxicol Sci, 2010 Dec. PMID 20864627, Free PMC Article
    2. Cytochrome P450-dependent metabolism of PCB52 in the nematode Caenorhabditis elegans. Schäfer P, et al. Arch Biochem Biophys, 2009 Aug 1. PMID 19563772
    3. Minimal modulation of macrocyclic lactone susceptibility in Caenorhabditis elegans following inhibition of cytochrome P450 monooxygenase activity. Yilmaz E, et al. Exp Parasitol, 2019 May. PMID 30946841
    4. Specific regulation of thermosensitive lipid droplet fusion by a nuclear hormone receptor pathway. Li S, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28760992, Free PMC Article
    5. CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation. Keller J, et al. Biochem J, 2014 Nov 15. PMID 25138176

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH-hemoprotein reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH-hemoprotein reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in eggshell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitric oxide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADPH--cytochrome P450 reductase
    NP_498103.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5196680..5199677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065702.8 → NP_498103.1  NADPH--cytochrome P450 reductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09590
      Conserved Domains (3) summary
      cd06204
      Location:268 → 661
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      COG0369
      Location:43 → 661
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:75 → 212
      Flavodoxin_1; Flavodoxin
    Nucleotide Protein
    Heading Accession and Version

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