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    elo-5 Long chain fatty acid elongase 5 [ Caenorhabditis elegans ]

    Gene ID: 177320, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elo-5
    Official Full Name
    Long chain fatty acid elongase 5
    Primary source
    WormBase:WBGene00001243
    Locus tag
    CELE_F41H10.7
    See related
    AllianceGenome:WB:WBGene00001243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid elongase activity. Involved in methyl-branched fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in amphid neurons and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elo-5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (5374616..5377117, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene GRIP domain-containing protein Neighboring gene Vacuolar fusion protein MON1 homolog Neighboring gene PHD-type domain-containing protein;RNA-directed RNA polymerase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C. elegans. Kniazeva M, et al. Dev Cell, 2015 May 4. PMID 25892013
    2. LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans. Entchev EV, et al. J Biol Chem, 2008 Jun 20. PMID 18390550
    3. Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans. Zhu H, et al. Genes Dev, 2015 Jun 15. PMID 26109047, Free PMC Article
    4. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. Zhu H, et al. Elife, 2013 May 21. PMID 23705068, Free PMC Article
    5. Oleic Acid Metabolism in Response to Glucose in C. elegans. Vieira AFC, et al. Metabolites, 2023 Dec 6. PMID 38132867, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. elo-5 and elo-6 may be transcriptional targets of LPD-1
      Title: Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methyl-branched fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Long chain fatty acid elongase 5
    NP_001368393.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5374616..5377117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380227.3 → NP_001368393.1  Long chain fatty acid elongase 5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20300, V6CLH1
      Conserved Domains (1) summary
      pfam01151
      Location:24 → 258
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20300.2

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