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    nhx-8 Sodium/hydrogen exchanger [ Caenorhabditis elegans ]

    Gene ID: 189474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhx-8
    Official Full Name
    Sodium/hydrogen exchanger
    Primary source
    WormBase:WBGene00003735
    Locus tag
    CELE_Y18D10A.6
    See related
    AllianceGenome:WB:WBGene00003735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport and regulation of intracellular pH. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary muscle; hypodermis; nervous system; pharyngeal-intestinal valve; and rectal valve cell. Orthologous to human SLC9A8 (solute carrier family 9 member A8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhx-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (12825664..12834163)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Glycogen synthase kinase-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene Eukaryotic translation initiation factor 4E-binding protein Mextli homolog Neighboring gene putative cytosolic iron-sulfur protein assembly protein CIAO1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A DNA nanodevice for mapping sodium at single-organelle resolution. Zou J, et al. Nat Biotechnol, 2024 Jul. PMID 37735265, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/hydrogen exchanger
    NP_001021728.1
    • Confirmed by transcript evidence
    NP_001021729.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12825664..12834163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026557.4 → NP_001021728.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021728.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBN7
      Conserved Domains (1) summary
      COG0025
      Location:109 → 517
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

    2. NM_001026558.5 → NP_001021729.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021729.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFN1
      Conserved Domains (1) summary
      COG0025
      Location:83 → 491
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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