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    tsfm-1 Elongation factor Ts, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 179683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tsfm-1
    Official Full Name
    Elongation factor Ts, mitochondrial
    Primary source
    WormBase:WBGene00010094
    Locus tag
    CELE_F55C5.5
    See related
    AllianceGenome:WB:WBGene00010094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tsfm-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (12270271..12271551, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Potassium channel domain-containing protein Neighboring gene CAP-G condensin subunit Neighboring gene Basonuclin zinc finger protein homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the interaction between the nucleotide exchange factor EF-Ts from nematode mitochondria and elongation factor Tu. Ohtsuki T, et al. Nucleic Acids Res, 2002 Dec 15. PMID 12490713, Free PMC Article
    2. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans. Emerson FJ, et al. Nat Commun, 2024 Mar 14. PMID 38485937, Free PMC Article
    3. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923
    4. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongation factor Ts, mitochondrial
    NP_506079.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12270271..12271551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073678.6 → NP_506079.1  Elongation factor Ts, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20819
      Conserved Domains (3) summary
      PRK12332
      Location:25 → 187
      tsf; elongation factor Ts; Reviewed
      cd14275
      Location:28 → 65
      UBA_EF-Ts; UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes
      pfam00889
      Location:97 → 314
      EF_TS; Elongation factor TS
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20819.1

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