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    dyf-18 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186662, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyf-18
    Official Full Name
    Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00010349
    Locus tag
    CELE_H01G02.2
    See related
    AllianceGenome:WB:WBGene00010349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to be active in nucleus. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human CDK20 (cyclin dependent kinase 20). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dyf-18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (11798654..11801178, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BRCT domain-containing protein Neighboring gene Apple domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DYF-5 RCK and CDKL-1 CDKL5 kinases contribute differentially to shape distinct sensory neuron cilia morphologies in C. elegans. Maurya AK, et al. MicroPubl Biol, 2022. PMID 35996689, Free PMC Article
    2. xbx-4, a homolog of the Joubert syndrome gene FAM149B1, acts via the CCRK and RCK kinase cascade to regulate cilia morphology. Maurya AK, et al. Curr Biol, 2021 Dec 20. PMID 34731674, Free PMC Article
    3. The kinases male germ cell-associated kinase and cell cycle-related kinase regulate kinesin-2 motility in Caenorhabditis elegans neuronal cilia. Yi P, et al. Traffic, 2018 Jul. PMID 29655266
    4. Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport. Phirke P, et al. Dev Biol, 2011 Sep 1. PMID 21740898, Free PMC Article
    5. RNA editing restricts hyperactive ciliary kinases. Li D, et al. Science, 2021 Aug 27. PMID 34446600

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In C. elegans, DYF-18/CCRK and DYF-5/MAK act in a cascade to generate the highly arborized cilia morphologies of the AWA olfactory neurons. Loss of kinase function results in dramatically elongated AWA cilia that lack branches.
      Title: A CCRK and a MAK Kinase Modulate Cilia Branching and Length via Regulation of Axonemal Microtubule Dynamics in Caenorhabditis elegans.
    2. dyf-18 stabilizes interaction between intraflagellar transport particles and OSM-3-kinesin in neuronal cilia.
      Title: The kinases male germ cell-associated kinase and cell cycle-related kinase regulate kinesin-2 motility in Caenorhabditis elegans neuronal cilia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein
    NP_502232.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11798654..11801178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069831.3 → NP_502232.2  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502232.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17903
      Conserved Domains (1) summary
      cl21453
      Location:7 → 289
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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