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    ZK1236.1 Translation factor GUF1 homolog, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 176191, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZK1236.1
    Official Full Name
    Translation factor GUF1 homolog, mitochondrial
    Primary source
    WormBase:WBGene00022862
    Locus tag
    CELE_ZK1236.1
    See related
    AllianceGenome:WB:WBGene00022862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in positive regulation of translation. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZK1236.1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (8429297..8431621)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Chromo domain-containing protein cec-1 Neighboring gene Uncharacterized protein Neighboring gene TPR_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Translation factor GUF1 homolog, mitochondrial
    NP_498863.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8429297..8431621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066462.5 → NP_498863.1  Translation factor GUF1 homolog, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498863.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34617
      Conserved Domains (6) summary
      cd01890
      Location:43 → 214
      LepA; LepA also known as Elongation Factor 4 (EF4)
      PRK05433
      Location:39 → 644
      PRK05433; GTP-binding protein LepA; Provisional
      cd03709
      Location:445 → 523
      lepA_C; lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits ...
      pfam06421
      Location:532 → 644
      LepA_C; GTP-binding protein LepA C-terminus
      cd03699
      Location:222 → 305
      EF4_II; Domain II of Elongation Factor 4 (EF4)
      cd16260
      Location:326 → 401
      EF4_III; Domain III of Elongation Factor 4 (EF4)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34617.2

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