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    rpoa-1 DNA-directed RNA polymerase;DNA-directed RNA polymerase subunit [ Caenorhabditis elegans ]

    Gene ID: 175015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpoa-1
    Official Full Name
    DNA-directed RNA polymerase;DNA-directed RNA polymerase subunit
    Primary source
    WormBase:WBGene00012999
    Locus tag
    CELE_Y48E1A.1
    See related
    AllianceGenome:WB:WBGene00012999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rpoa-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (13670626..13694795, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene WH1 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Potassium voltage-gated channel subfamily KQT member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    2. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase;DNA-directed RNA polymerase subunit
    NP_001022450.1
    • Confirmed by transcript evidence
    NP_001022451.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13670626..13694795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027279.5 → NP_001022450.1  DNA-directed RNA polymerase subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022450.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED21
      Conserved Domains (3) summary
      cd02735
      Location:1223 → 1711
      RNAP_I_Rpa1_C; Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
      PRK14977
      Location:10 → 1713
      PRK14977; bifunctional DNA-directed RNA polymerase A'/A'' subunit; Provisional
      cd01435
      Location:23 → 1040
      RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain

    2. NM_001027280.6 → NP_001022451.1  DNA-directed RNA polymerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDG7
      Conserved Domains (1) summary
      cl29012
      Location:2 → 94
      RNAP_largest_subunit_C; Largest subunit of RNA polymerase (RNAP), C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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