hda-2 Putative histone deacetylase 2 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: hda-2
Official Full Name: Putative histone deacetylase 2
Primary source: WormBase:WBGene00001835
Locus tag: CELE_C08B11.2
See related: AllianceGenome:WB:WBGene00001835
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable histone deacetylase activity and transcription corepressor activity. Involved in DNA protection and nematode male tail tip morphogenesis. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Is expressed in distal tip cell; gonadal sheath cell; nerve ring; pharynx; and uterus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA protection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_495678.1

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The following sections contain reference sequences that belong to a specific genome build. Explain