rpt-6 26S proteasome regulatory subunit 8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpt-6
Official Full Name: 26S proteasome regulatory subunit 8
Primary source: WormBase:WBGene00004506
Locus tag: CELE_Y49E10.1
See related: AllianceGenome:WB:WBGene00004506
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpt-6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (12370456..12372607)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study results indicate that C. elegans RPT-6 interacts with ELT-2 in vivo to control the expression of immune genes during response to Pseudomonas aeruginosa infection in a manner that is likely independent of the proteolytic activity of the proteasome.
Title: Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y49E10.1 (e-PCR)
- UniSTS:317318

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome regulatory subunit 8

NP_499609.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12370456..12372607

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067208.6 → NP_499609.1 26S proteasome regulatory subunit 8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499609.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XTT9

Conserved Domains (1) summary

COG1222
Location:10 → 414

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]