ubc-1 Ubiquitin-conjugating enzyme E2 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ubc-1
Official Full Name: Ubiquitin-conjugating enzyme E2 1
Primary source: WormBase:WBGene00006701
Locus tag: CELE_C35B1.1
See related: AllianceGenome:WB:WBGene00006701
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in DNA repair and protein ubiquitination. Part of ubiquitin conjugating enzyme complex. Is expressed in several structures, including hypodermis; intestine; nervous system; rectal gland cell; and tail. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Nascimento type. Orthologous to several human genes including UBE2B (ubiquitin conjugating enzyme E2 B). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein modification by small protein conjugation	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of HULC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin conjugating enzyme complex	IDA Inferred from Direct Assay more info	PubMed

NP_001379774.1

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