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    unc-87 Protein unc-87 [ Caenorhabditis elegans ]

    Gene ID: 172397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-87
    Official Full Name
    Protein unc-87
    Primary source
    WormBase:WBGene00006819
    Locus tag
    CELE_F08B6.4
    See related
    AllianceGenome:WB:WBGene00006819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables actin filament binding activity; cytoskeletal motor inhibitor activity; and myosin binding activity. Involved in actin cytoskeleton organization and negative regulation of muscle filament sliding. Located in I band; stress fiber; and striated muscle thin filament. Part of actomyosin, myosin complex part. Is expressed in several structures, including non-striated muscle; pharynx; spermatheca; ventral ganglion; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-87 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (6761221..6767797, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene G protein gamma domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene BPH_3 domain-containing protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two Caenorhabditis elegans calponin-related proteins have overlapping functions that maintain cytoskeletal integrity and are essential for reproduction.
      Title: Two Caenorhabditis elegans calponin-related proteins have overlapping functions that maintain cytoskeletal integrity and are essential for reproduction.
    2. Both UNC-87 isoforms bind to actin filaments and myosin to induce ATP-resistant actomyosin bundles and inhibit actomyosin motility.
      Title: UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility.
    3. Data show that UNC-87 competes with ADF/cofilin (unc-60) for binding to actin filaments and inhibits ADF/cofilin-dependent filament severing and depolymerization in vitro.
      Title: UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytoskeletal motor inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin structure organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actomyosin structure organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myosin filament assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of muscle filament sliding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of muscle filament sliding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in I band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in I band IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of actomyosin, myosin complex part IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein unc-87
    NP_001021092.1
    • Confirmed by transcript evidence
    NP_001021093.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6761221..6767797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025921.5 → NP_001021092.1  Protein unc-87 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P37806, Q6EZG6, Q9TYS6
      Conserved Domains (1) summary
      pfam00402
      Location:434 → 454
      Calponin; Calponin family repeat

    2. NM_001025922.6 → NP_001021093.1  Protein unc-87 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6LD30
      Conserved Domains (1) summary
      pfam00402
      Location:243 → 263
      Calponin; Calponin family repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37806.3

    Gene LinkOut

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