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    lbp-8 Fatty acid-binding protein homolog 8 [ Caenorhabditis elegans ]

    Gene ID: 188761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lbp-8
    Official Full Name
    Fatty acid-binding protein homolog 8
    Primary source
    WormBase:WBGene00002260
    Locus tag
    CELE_T22G5.6
    See related
    AllianceGenome:WB:WBGene00002260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables long-chain fatty acid transmembrane transporter activity and oleic acid binding activity. Involved in long-chain fatty acid transport. Located in lysosome and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1G. Orthologous to several human genes including FABP12 (fatty acid binding protein 12); FABP7 (fatty acid binding protein 7); and FABP9 (fatty acid binding protein 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lbp-8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (13890773..13891364)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Saposin B-type domain-containing protein Neighboring gene ncRNA Neighboring gene Serine palmitoyltransferase 3 Neighboring gene CYtochrome P450 family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity. Ramachandran PV, et al. Dev Cell, 2019 Mar 11. PMID 30713071, Free PMC Article
    2. Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. Tillman MC, et al. Sci Rep, 2019 Jul 10. PMID 31292465, Free PMC Article
    3. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Folick A, et al. Science, 2015 Jan 2. PMID 25554789, Free PMC Article
    4. Secretion of a novel class of iFABPs in nematodes: coordinate use of the Ascaris/Caenorhabditis model systems. Plenefisch J, et al. Mol Biochem Parasitol, 2000 Feb 5. PMID 10693745
    5. Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan. Oh M, et al. Sci Rep, 2022 May 3. PMID 35504961, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables long-chain fatty acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oleic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in long-chain fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fatty acid-binding protein homolog 8
    NP_506444.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13890773..13891364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074043.6 → NP_506444.2  Fatty acid-binding protein homolog 8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506444.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02324
      Conserved Domains (1) summary
      cd00742
      Location:6 → 136
      FABP; intracellular fatty acid-binding protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02324.2

    Gene LinkOut

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