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    nlp-12 Neuropeptide-Like Protein [ Caenorhabditis elegans ]

    Gene ID: 171753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nlp-12
    Official Full Name
    Neuropeptide-Like Protein
    Primary source
    WormBase:WBGene00003750
    Locus tag
    CELE_M01D7.5
    See related
    AllianceGenome:WB:WBGene00003750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cholecystokinin receptor binding activity. Involved in foraging behavior and neuropeptide signaling pathway. Located in neuron projection and neuronal cell body. Is expressed in PVDL; PVDR; coelomocyte; and tail neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nlp-12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (1843384..1843959)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Guanine nucleotide-binding protein subunit alpha Neighboring gene ncRNA Neighboring gene Emerin homolog 1 Neighboring gene GHMP kinase C-terminal domain-containing protein;Galactokinase Neighboring gene 7TM_GPCR_Srx domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analogs of sulfakinin-related peptides demonstrate reduction in food intake in the red flour beetle, Tribolium castaneum, while putative antagonists increase consumption. Yu N, et al. Peptides, 2013 Mar. PMID 23246802
    2. Gene expression and pharmacology of nematode NLP-12 neuropeptides. McVeigh P, et al. Int J Parasitol, 2006 May 31. PMID 16600246
    3. In the proper context: Neuropeptide regulation of behavioral transitions during food searching. Bhattacharya R, et al. Worm, 2015 Jul-Sep. PMID 26430569, Free PMC Article
    4. A pharmacological study of NLP-12 neuropeptide signaling in free-living and parasitic nematodes. Peeters L, et al. Peptides, 2012 Mar. PMID 22019590
    5. A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior. Bhattacharya R, et al. PLoS Genet, 2014 Aug. PMID 25167143, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NLP-12 adjusts tonic and evoked release at neuromuscular junctions by distinct mechanisms
      Title: NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release.
    2. NLP-12 release from DVA is regulated through the D1-like dopamine receptor DOP-1, and both nlp-12 and dop-1 are required for normal local food searching responses
      Title: A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior.
    3. results suggest that NLP-12 mediates a mechanosensory feedback loop that couples muscle contraction to changes in presynaptic release.
      Title: A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cholecystokinin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in foraging behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Neuropeptide-Like Protein
    NP_490908.1
    • Product from WormBase gene class nlp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1843384..1843959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058507.8 → NP_490908.1  Neuropeptide-Like Protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01970
    Nucleotide Protein
    Heading Accession and Version

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