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    szy-20 SUZ domain-containing protein;Suppressor of zyg-1 protein 20 [ Caenorhabditis elegans ]

    Gene ID: 174430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    szy-20
    Official Full Name
    SUZ domain-containing protein;Suppressor of zyg-1 protein 20
    Primary source
    WormBase:WBGene00004105
    Locus tag
    CELE_C18E9.3
    See related
    AllianceGenome:WB:WBGene00004105
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Involved in several processes, including negative regulation of protein localization to centrosome; positive regulation of fertilization; and regulation of cell cycle process. Located in centrosome; cytoplasm; and nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See szy-20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8966921..8969333, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Neighboring gene Translocation protein SEC62 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial import receptor subunit TOM40 homolog Neighboring gene Fibronectin type-III domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Song MH, et al. Dev Cell, 2008 Dec. PMID 19081077, Free PMC Article
    2. Correction: ATX-2, The C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. Stubenvoll MD, et al. PLoS Genet, 2016 Dec. PMID 28027322, Free PMC Article
    3. Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos. Medley JC, et al. Biol Open, 2017 Jan 15. PMID 27881437, Free PMC Article
    4. ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. Stubenvoll MD, et al. PLoS Genet, 2016 Sep. PMID 27689799, Free PMC Article
    5. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Song MH, et al. Dev Cell, 2011 Apr 19. PMID 21497766, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to centrosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fertilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of centrosome duplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle, embryonic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitotic cytokinetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of spindle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUZ domain-containing protein;Suppressor of zyg-1 protein 20
    NP_001021977.2
    • Confirmed by transcript evidence
    NP_001122590.1
    • Confirmed by transcript evidence
    NP_001129808.1
    • Confirmed by transcript evidence
    NP_001254187.1
    • Confirmed by transcript evidence
    NP_001254188.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8966921..8969333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136336.3 → NP_001129808.1  Suppressor of zyg-1 protein 20 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129808.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGU9
      Conserved Domains (1) summary
      pfam12752
      Location:69 → 145
      SUZ; SUZ domain

    2. NM_001026806.7 → NP_001021977.2  SUZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021977.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q565A8
      Conserved Domains (1) summary
      pfam12752
      Location:69 → 146
      SUZ; SUZ domain

    3. NM_001129118.4 → NP_001122590.1  SUZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2D6L4
      Conserved Domains (1) summary
      pfam12752
      Location:72 → 149
      SUZ; SUZ domain

    4. NM_001267258.3 → NP_001254187.1  Suppressor of zyg-1 protein 20 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254187.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9P338, A9P339, G5EEB4, G5EGU9
      Conserved Domains (1) summary
      pfam12752
      Location:69 → 146
      SUZ; SUZ domain

    5. NM_001267259.3 → NP_001254188.1  SUZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2KT99
      Conserved Domains (1) summary
      pfam12752
      Location:72 → 149
      SUZ; SUZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EGU9.1

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