vha-7 V-type proton ATPase 116 kDa subunit a 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vha-7
Official Full Name: V-type proton ATPase 116 kDa subunit a 4
Primary source: WormBase:WBGene00006916
Locus tag: CELE_C26H9A.1
See related: AllianceGenome:WB:WBGene00006916
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase binding activity. Predicted to be involved in vacuolar acidification. Predicted to be located in membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be active in plasma membrane. Is expressed in gonad; hypodermis; and oocyte. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vha-7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 25

Sequence:: Chromosome: IV; NC_003282.8 (12640462..12650652)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

C26H9A.1 (e-PCR)
- UniSTS:318919

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: V-type proton ATPase 116 kDa subunit a 4

NP_001299937.1

Confirmed by transcript evidence

NP_001379242.1

Confirmed by transcript evidence

NP_001379486.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12640462..12650652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392418.1 → NP_001379486.1 V-type proton ATPase 116 kDa subunit a 4 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AXB9, B2MZD0, G5EDH1

Conserved Domains (1) summary

pfam01496
Location:316 → 1181

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_001313008.3 → NP_001299937.1 V-type proton ATPase 116 kDa subunit a 4 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AXB9
NM_001392419.1 → NP_001379242.1 V-type proton ATPase 116 kDa subunit a 4 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam01496
Location:71 → 937

V_ATPase_I; V-type ATPase 116kDa subunit family