emb-5 Suppressor of Ty 6 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: emb-5
Official Full Name: Suppressor of Ty 6 homolog
Primary source: WormBase:WBGene00001259
Locus tag: CELE_T04A8.14
See related: AllianceGenome:WB:WBGene00001259
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome organization and transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Is expressed in intestine; nervous system; pharynx; and tail. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See emb-5 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (4715293..4720670, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T04A8.14 (e-PCR)
- UniSTS:306531

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Suppressor of Ty 6 homolog

NP_497969.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4715293..4720670 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065568.4 → NP_497969.1 Suppressor of Ty 6 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497969.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34703, Q7JMP9

Conserved Domains (9) summary

cd09918
Location:1299 → 1383

SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6

cd09928
Location:1392 → 1485

SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6

pfam00575
Location:1182 → 1251

S1; S1 RNA binding domain

pfam09371
Location:533 → 593

Tex_N; Tex-like protein N-terminal domain

pfam14633
Location:1271 → 1484

SH2_2; SH2 domain

pfam14641
Location:294 → 415

HTH_44; Helix-turn-helix DNA-binding domain of SPT6

pfam14878
Location:1022 → 1119

DLD; Death-like domain of SPT6

cl21482
Location:749 → 899

RuvC_resolvase; Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes ...

cl22429
Location:904 → 1007

HHH_5; Helix-hairpin-helix domain