spe-41 Transient receptor ion channel domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spe-41
Official Full Name: Transient receptor ion channel domain-containing protein
Primary source: WormBase:WBGene00004976
Locus tag: CELE_K01A11.4
See related: AllianceGenome:WB:WBGene00004976
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables store-operated calcium channel activity. Involved in calcium ion transport; intracellular calcium ion homeostasis; and single fertilization. Located in cytoplasmic vesicle and pseudopodium membrane. Is expressed in sperm and spermatid. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spe-41 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 15

Sequence:: Chromosome: III; NC_003281.10 (3439011..3444210, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a novel genetic and physical interaction between two critical sperm function molecules, SPE-38 and TRP-3/SPE-41 in C. elegans was unraveled.
Title: The sperm surface localization of the TRP-3/SPE-41 Ca2+ -permeable channel depends on SPE-38 function in Caenorhabditis elegans.
identifed a sperm-enriched TRPC homolog, TRP-3; mutations lead to sterility in both hermaphrodites and males due to a defect in their sperm; mutant sperm are motile, but fail to fertilize oocytes after gamete contact.
Title: A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K01A11.4 (e-PCR)
- UniSTS:311342

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in pseudopodium membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Transient receptor ion channel domain-containing protein

NP_001254872.1

Confirmed by transcript evidence

NP_001379535.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3439011..3444210 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267943.4 → NP_001254872.1 Transient receptor ion channel domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254872.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EF09

Conserved Domains (1) summary

TIGR00870
Location:87 → 671

trp; transient-receptor-potential calcium channel protein
NM_001393307.1 → NP_001379535.1 Transient receptor ion channel domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G3MTY7

Conserved Domains (1) summary

TIGR00870
Location:2 → 528

trp; transient-receptor-potential calcium channel protein