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    otub-3 OTU domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    otub-3
    Official Full Name
    OTU domain-containing protein
    Primary source
    WormBase:WBGene00009007
    Locus tag
    CELE_F21D5.2
    See related
    AllianceGenome:WB:WBGene00009007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Is expressed in nervous system. Orthologous to human OTUD6A (OTU deubiquitinase 6A) and OTUD6B (OTU deubiquitinase 6B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See otub-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (8728177..8730510)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Phosphoacetylglucosamine mutase Neighboring gene ncRNA Neighboring gene Multicopper oxidase;Plastocyanin-like domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene HTH CENPB-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    OTU domain-containing protein
    NP_001255318.1
    • Confirmed by transcript evidence
    NP_001255319.1
    • Partially confirmed by transcript evidence
    NP_001255320.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8728177..8730510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268389.4 → NP_001255318.1  OTU domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19681
      Conserved Domains (2) summary
      COG5539
      Location:3 → 305
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
      pfam02338
      Location:173 → 303
      OTU; OTU-like cysteine protease

    2. NM_001268390.4 → NP_001255319.1  OTU domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GU86
      Conserved Domains (1) summary
      pfam02338
      Location:194 → 324
      OTU; OTU-like cysteine protease

    3. NM_001268391.3 → NP_001255320.1  OTU domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GU87
      Conserved Domains (1) summary
      pfam02338
      Location:132 → 262
      OTU; OTU-like cysteine protease
    Nucleotide Protein
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