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    spop-1 Speckle-type POZ protein homolog [ Caenorhabditis elegans ]

    Gene ID: 176422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spop-1
    Official Full Name
    Speckle-type POZ protein homolog
    Primary source
    WormBase:WBGene00011815
    Locus tag
    CELE_T16H12.5
    See related
    AllianceGenome:WB:WBGene00011815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to several human genes including SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spop-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (10090862..10098081, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Coiled-coil domain-containing protein Neighboring gene General transcription factor IIH subunit 2 Neighboring gene Kelch repeat-containing protein kel-10 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SPOP loss of function protects against tauopathy. Eck RJ, et al. Proc Natl Acad Sci U S A, 2023 Jan 3. PMID 36574656, Free PMC Article
    2. Superoxide dismutase SOD-3 regulates redox homeostasis in the intestine. Wong CH, et al. MicroPubl Biol, 2023. PMID 38188420, Free PMC Article
    3. Deficiency of cardiolipin synthase causes abnormal mitochondrial function and morphology in germ cells of Caenorhabditis elegans. Sakamoto T, et al. J Biol Chem, 2012 Feb 10. PMID 22174409, Free PMC Article
    4. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity. Snoznik C, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34593637, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Speckle-type POZ protein homolog
    NP_001022764.1
    • Confirmed by transcript evidence
    NP_001022765.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10090862..10098081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027593.2 → NP_001022764.1  Speckle-type POZ protein homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022764.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34568, Q5CZ49
      Conserved Domains (4) summary
      smart00225
      Location:266 → 368
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd03774
      Location:92 → 230
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd14734
      Location:368 → 430
      SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:255 → 365
      BTB; BTB/POZ domain

    2. NM_001027594.6 → NP_001022765.1  Speckle-type POZ protein homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022765.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34568
      Conserved Domains (4) summary
      smart00225
      Location:224 → 326
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd03774
      Location:50 → 188
      MATH_SPOP; Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled ...
      cd14734
      Location:326 → 388
      SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:213 → 323
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34568.2

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