U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lsy-2 Zinc finger protein lsy-2 [ Caenorhabditis elegans ]

    Gene ID: 180522, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lsy-2
    Official Full Name
    Zinc finger protein lsy-2
    Primary source
    WormBase:WBGene00003087
    Locus tag
    CELE_F49H12.1
    See related
    AllianceGenome:WB:WBGene00003087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in nematode larval development; neuron fate specification; and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including anal region; epithelial system; head; intestine; and nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lsy-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (2089704..2093256)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein 154

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cell fate simulation model of gustatory neurons with MicroRNAs double-negative feedback loop by hybrid functional Petri net with extension. Saito A, et al. Genome Inform, 2006. PMID 17503360
    2. Caenorhabditis elegans as an undergraduate educational tool for teaching RNAi. Andersen J, et al. Biochem Mol Biol Educ, 2008 Nov. PMID 21591231
    3. A novel C. elegans zinc finger transcription factor, lsy-2, required for the cell type-specific expression of the lsy-6 microRNA. Johnston RJ Jr, et al. Development, 2005 Dec. PMID 16291785
    4. LSY-2 is essential for maintaining the germ-soma distinction in C. elegans. Lin L, et al. Protein Cell, 2015 Aug. PMID 26050091, Free PMC Article
    5. Transcriptional control of microRNA expression in C. elegans: promoting better understanding. Turner MJ, et al. RNA Biol, 2009 Jan-Mar. PMID 19106630, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Zinc finger protein lsy-2
    NP_001024696.1
    • Confirmed by transcript evidence
    NP_001024697.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2089704..2093256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029525.5 → NP_001024696.1  Zinc finger protein lsy-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024696.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4ZG90, Q9N5S3
      Conserved Domains (4) summary
      COG5048
      Location:102 → 156
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:80 → 100
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:134 → 156
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:93 → 115
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001029526.4 → NP_001024697.1  Zinc finger protein lsy-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4ZG90
      Conserved Domains (4) summary
      COG5048
      Location:76 → 130
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:54 → 74
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:108 → 130
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:67 → 89
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N5S3.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools