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    osg-1 Rho guanine nucleotide exchange factor osg-1 [ Caenorhabditis elegans ]

    Gene ID: 175756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    osg-1
    Official Full Name
    Rho guanine nucleotide exchange factor osg-1
    Primary source
    WormBase:WBGene00019832
    Locus tag
    CELE_R02F2.2
    See related
    AllianceGenome:WB:WBGene00019832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in response to oxidative stress. Predicted to be active in cytoplasm. Is expressed in body wall musculature and head neurons. Orthologous to human ARHGEF17 (Rho guanine nucleotide exchange factor 17). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See osg-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    17
    Sequence:
    Chromosome: III; NC_003281.10 (5487553..5498958)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Myb-binding protein 1A-like protein Neighboring gene Chitin-binding type-2 domain-containing protein Neighboring gene Amino acid transporter transmembrane domain-containing protein Neighboring gene Large ribosomal subunit protein mL62 Neighboring gene Cyclin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoskeletal remodeling via Rho GTPases during oxidative and thermal stress in Caenorhabditis elegans. Patel R, et al. Biochem Biophys Res Commun, 2017 Oct 21. PMID 28859988, Free PMC Article
    2. Guanine nucleotide exchange factor OSG-1 confers functional aging via dysregulated Rho signaling in Caenorhabditis elegans neurons. Duan Z, et al. Genetics, 2015 Feb. PMID 25527286, Free PMC Article
    3. CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo. Kumfer KT, et al. Mol Biol Cell, 2010 Jan 15. PMID 19923324, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho guanine nucleotide exchange factor osg-1
    NP_498172.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5487553..5498958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065771.7 → NP_498172.3  Rho guanine nucleotide exchange factor osg-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498172.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21653
      Conserved Domains (2) summary
      smart00325
      Location:361 → 543
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:524 → 612
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21653.4

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