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    lin-22 Helix-loop-helix protein lin-22 [ Caenorhabditis elegans ]

    Gene ID: 177082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-22
    Official Full Name
    Helix-loop-helix protein lin-22
    Primary source
    WormBase:WBGene00003008
    Locus tag
    CELE_Y54G2A.1
    See related
    AllianceGenome:WB:WBGene00003008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; negative regulation of gene expression; and nematode male tail tip morphogenesis. Acts upstream of or within epidermal cell fate specification. Predicted to be active in nucleus. Is expressed in several structures, including intestine; nervous system; pharynx; seam cell; and uterus. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lin-22 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (3019738..3023304)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Vitellogenin Regulating Protein Neighboring gene ncRNA Neighboring gene Protein NDNF C-terminal domain-containing protein Neighboring gene HECT-type E3 ubiquitin transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number. Katsanos D, et al. PLoS Biol, 2017 Nov. PMID 29108019, Free PMC Article
    2. The synaptonemal complexes of Caenorhabditis elegans: pachytene karyotype analysis of hermaphrodites from the recessive him-5 and him-7 mutants. Goldstein P. J Cell Sci, 1986 Jun. PMID 3793776
    3. Targeted DamID in C. elegans reveals a direct role for LIN-22 and NHR-25 in antagonizing the epidermal stem cell fate. Katsanos D, et al. Sci Adv, 2022 Feb 4. PMID 35119932, Free PMC Article
    4. Age-related changes in the meiotic chromosomes of the nematode Caenorhabditis elegans. Goldstein P, et al. Mech Ageing Dev, 1987 Sep 30. PMID 3431155
    5. A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit. Weston K, et al. Nucleic Acids Res, 1989 Mar 11. PMID 2928124, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epidermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Helix-loop-helix protein lin-22
    NP_500281.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3019738..3023304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067880.6 → NP_500281.1  Helix-loop-helix protein lin-22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500281.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EF76
      Conserved Domains (1) summary
      cd11410
      Location:29 → 82
      bHLH_O_HES; basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EF76.1

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