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    wrb-1 Guided entry of tail-anchored proteins factor 1 [ Caenorhabditis elegans ]

    Gene ID: 178617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wrb-1
    Official Full Name
    Guided entry of tail-anchored proteins factor 1
    Primary source
    WormBase:WBGene00021736
    Locus tag
    CELE_Y50D4A.2
    See related
    AllianceGenome:WB:WBGene00021736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-membrane adaptor activity. Predicted to be involved in tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of GET complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wrb-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (1196072..1197141)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mic1 domain-containing protein Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Reverse transcriptase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unique Features of Satellite DNA Transcription in Different Tissues of Caenorhabditis elegans. Subirana JA, et al. Int J Mol Sci, 2023 Feb 3. PMID 36769294, Free PMC Article
    2. Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans. Raj D, et al. Sci Rep, 2021 Apr 21. PMID 33883621, Free PMC Article
    3. Functional transcriptomics of a migrating cell in Caenorhabditis elegans. Schwarz EM, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22991463, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Guided entry of tail-anchored proteins factor 1
    NP_001255993.1
    • Confirmed by transcript evidence
    NP_001379795.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1196072..1197141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269064.4 → NP_001255993.1  Guided entry of tail-anchored proteins factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WTM8
      Conserved Domains (1) summary
      pfam04420
      Location:24 → 122
      CHD5; CHD5-like protein

    2. NM_001392472.1 → NP_001379795.1  Guided entry of tail-anchored proteins factor 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4S708
      Conserved Domains (1) summary
      pfam04420
      Location:10 → 118
      CHD5; CHD5-like protein
    Nucleotide Protein
    Heading Accession and Version

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